Japan Best Proteoglycan – Latest Innovative Joint Remedies

• Promote cartilage regeneration
• Improvement of the bone metabolism
• Anti-Inflammatory

Introducing New Era of treatment to stop the early stages of osteoarthritis & a NEW POTENTIAL of exogenous cartilage proteoglycan as a new material for cartilage regeneration.

What is Proteoglycan?

Proteoglycan is a kind of glycoprotein in a broad sense that sulfated polysaccharide called glycosaminoglycan such as chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin, and keratan sulfate covalently bonded to the protein. Proteoglycan is present in the extracellular matrix and cell surfaces of humans. It is also present in the fibrous matrix and the cell surface of hyaluronic acid and collagen, forming fibrous matrix proteins and a complex of hyaluronic acid and collagen.

Proteoglycan is not easily decomposed by stomach acid. Therefore, it passes through the stomach while maintaining its high molecular state. Nevertheless, due to the decomposing enzymes in the small intestine, it is broken down to a certain size. This decomposition product becomes the immunizing antigen M cells (micro-fold cells) as it passes through, which has been thought to bind with immune cells. Finally, it is considered to be enzymatically decomposed in the liver. The balance that was not decomposed will be excreted in the urine.

Proteoglycan is Different from Collagen

Articular cartilage is the bluish gel-like tissue that covers the ends of bones. It is 4-6mm thick, softer than bone, and can be found on many joint surfaces. The type II collagen is the basis for articular cartilage, and its fibrillar network allows cartilage to entrap the proteoglycan aggregate. The synovial fluid, which is also a part of the articular cartilage, contains hyaluronic acid as its main component, which lubricates the articulating joints. The articular cartilage makes joints easier to move and allows the bones to glide over each other with very little friction.

Between the cells, there is a jelly-like substance called the extracellular matrix. Common ingredients that compose this extracellular matrix are hyaluronic acid and collagen, but research has revealed that proteoglycan is the most important ingredient among them. Not only does it provide high moisture retention, but it also promotes cell regeneration (similar to the effect of EGF) by generating additional collagen and hyaluronic acid.