Introducing New Era of treatment to stop the early stages of osteoarthritis & a NEW POTENTIAL of exogenous cartilage proteoglycan as a new material for cartilage regeneration.

What is Proteoglycan?

Proteoglycan is a kind of glycoprotein in a broad sense that sulfated polysaccharide called glycosaminoglycan such as chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin and keratan sulfate which are covalently bonded to the protein. Proteoglycan is present in the extracellular matrix and cell surfaces of animals. It is also in the fibrous matrix proteins and complex of hyaluronic acid and collagen.

Proteoglycan is not easily decomposed by the stomach acid. Therefore, it passed through the stomach maintaining its high molecular state. Nevertheless, due to the decomposing enzymes in the small intestine, it is broken down up to a certain size. This decomposition product becomes the immunizing antigen M cells (micro-fold cells) as it passes through and which has been thought to bind with the immune cells. Finally, it is considered to be enzymatically decomposed in the liver. The balance that was not decomposed will be excreted in the urine.

For Joint Pain

Articular cartilage is the bluish gel-like tissue that covers the ends of bones. It is 4-6mm thick, softer than bone, and can be found on many joint surfaces. The type II collagen is the basis for articular cartilage, and its fibrillar network allows cartilage to entrap the proteoglycan aggregate.

The synovial fluid, which is also a part of the articular cartilage, contains hyaluronic acid as its main component, which lubricates the articulating joints. The articular cartilage makes joints easier to move and allows the bones to glide over each other with very little friction.